Surfacing With Deficits of Spatial Learning in Old Age Neurotoxic Effects of Repetitive Inhibition of Oxidative Phosphorylation in Young Adults

نویسندگان

  • David Redish
  • Neil Schmitzer-Torbert
چکیده

[PDF] [Full Text] [Abstract] , March 28, 2007; 27 (13): 3548-3559. J. Neurosci. W. J. Kargo, B. Szatmary and D. A. Nitz Action-Reward Contingencies Adaptation of Prefrontal Cortical Firing Patterns and Their Fidelity to Changes in [PDF] [Full Text] [Abstract] , November 7, 2007; 27 (45): 12176-12189. J. Neurosci. A. Johnson and A. D. Redish Point Neural Ensembles in CA3 Transiently Encode Paths Forward of the Animal at a Decision [PDF] [Full Text] [Abstract] , December 1, 2007; 62 (12): 1352-1356. J. Gerontol. A Biol. Sci. Med. Sci. P. Lohmann and M. W. Riepe Surfacing With Deficits of Spatial Learning in Old Age Neurotoxic Effects of Repetitive Inhibition of Oxidative Phosphorylation in Young Adults [PDF] [Full Text] [Abstract] , December 1, 2007; 98 (6): 3780-3790. J Neurophysiol A. S. Tolias, A. S. Ecker, A. G. Siapas, A. Hoenselaar, G. A. Keliris and N. K. Logothetis Recording Chronically From the Same Neurons in Awake, Behaving Primates [PDF] [Full Text] [Abstract] , December 26, 2007; 27 (52): 14502-14514. J. Neurosci. B. Lau and P. W. Glimcher Action and Outcome Encoding in the Primate Caudate Nucleus

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Neurotoxic effects of repetitive inhibition of oxidative phosphorylation in young adults surfacing with deficits of spatial learning in old age.

Little is known about whether events in youth impact performance in old age. We examined spatial navigation in young (4.5 months) and middle-aged (9 months) CD-1 mice in a complex maze after treatment with 3-nitropropionate (3-np; 20 mg/kg body weight; 9 injections intraperitoneally [i.p.] every other day). Young mice treated with 3-np were examined in a mirror version of this maze in old age (...

متن کامل

Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex

Objective(s): Methamphetamine is a stimulant compound that penetrates readily into the central nervous system. Repeated exposure to methamphetamine leads to damage in the dopaminergic and serotonergic axons of selected brain regions. Previous studies showed that cinnamaldehyde improved memory impairment in animals. In the present study, we aimed to elucidate the effects of cinnamaldehyde on met...

متن کامل

Protective Effect of Short-term Administration of Ethanolic Saffron Extract on improvement of Cognitive Deficits and Decrement of Lipid Peroxidation induced by Ethidium Bromide in Experimental Models of MS

Introduction: Cognitive dysfunction is recognized as a significant feature of multiple sclerosis (MS). Oxidative stress plays an important role in the pathogenesis of MS. Toxic demyelination by ethidium bromide (EB) is one of the common methods for induction of MS, which leads to neuronal death by production of free radicals and enhancement of oxidative stress burden. According to previous p...

متن کامل

Normobaric hyperoxia preconditioning attenuates streptozotocin - induced impairments in spatial learning

Introduction: A large body of evidence points to oxidative stress as prime candidate mediating the behavioral impairments and memory deficits in Alzheimer's disease (AD). It has been demonstrated that hyperoxia preconditioning activates complex endogenous neuroprotective mechanisms including an increase in capacity of antioxidant defence mechanisms. The aim of this study was to investigate the ...

متن کامل

Protective Effects of Pelargonium graveolens Essential Oil on methomyl-Induced  Oxidative Stress and Spatial Working Memory Impairment in Association with Histopathological Changes in the Hippocampus of Male Wistar Rats

Introduction: Methomyl (MET) is a carbamate insecticide, used in agriculture and public health to eliminate harmful insects. Besides its advantages in agriculture, it causes neurotoxic effects. The aim of this study was to evaluate the effect of MET on Spatial Working Memory (SWM), oxidative stress parameters,  and histopathological changes in the hippocampus, as well as the possible protective...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2004